Application of N-heterocyclic carbene–Cu(I) complexes as catalysts in organic synthesis: a review

• Nosheen Beig,
• Varsha Goyal and
• Raj K. Bansal

Beilstein J. Org. Chem. 2023, 19, 1408–1442, doi:10.3762/bjoc.19.102

Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

• Umesh P. Aher,
• Dhananjai Srivastava,
• Girij P. Singh and
• Jayashree B. S

Beilstein J. Org. Chem. 2021, 17, 2680–2715, doi:10.3762/bjoc.17.182

Optical detection of di- and triphosphate anions with mixed monolayer-protected gold nanoparticles containing zinc(II)–dipicolylamine complexes

• Lena Reinke,
• Julia Bartl,
• Marcus Koch and
• Stefan Kubik

Beilstein J. Org. Chem. 2020, 16, 2687–2700, doi:10.3762/bjoc.16.219

• and Discussion Ligand synthesis. The ligands used in this work are depicted in Figure 1. All of them derived from lipoic acid, which was chosen as the anchor group because the immobilization of a cyclic disulfide on gold involves the formation of two Au–S bonds, causing the ligands to have a smaller

• tendency to migrate and a generally higher stability with respect to thiol-containing AuNPs [37][38][39]. A further advantage is the straightforward ligand synthesis, which does not require the use of protecting groups as in the case of thiols. The ligand 1 served as the solubilizing component and was

Architecture and synthesis of P,N-heterocyclic phosphine ligands

• Wisdom A. Munzeiwa,
• Bernard Omondi and
• Vincent O. Nyamori

Beilstein J. Org. Chem. 2020, 16, 362–383, doi:10.3762/bjoc.16.35

• basicity in one ligand. The body discusses the synthetic protocols which focus on P–C, P–N-bond formation, substrate and nucleophile types and different N-heterocycle construction strategies. Selected references are given in relation to the applications of the ligands. Keywords: ligand synthesis; P,N

• 102. Synthesis of pyrrolylphosphine ligands. Synthesis of phosphine guanidinium ligands. Synthesis of a polydentate aminophosphine ligand. Synthesis of quinolylphosphine ligands. Synthesis of N-(triazolylmethyl)phosphanamine ligands. Synthesis of oxazaphosphorines. Synthesis of paracyclophane

Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates

• Souad Kachbi-Khelfallah,
• Maelle Monteil,
• Margery Cortes-Clerget,
• Evelyne Migianu-Griffoni,
• Jean-Luc Pirat,
• Olivier Gager,
• Julia Deschamp and
• Marc Lecouvey

Beilstein J. Org. Chem. 2016, 12, 1366–1371, doi:10.3762/bjoc.12.130

• is a procedure developed in our laboratory to introduce the bisphosphonate from acyl chloride and tris(trimethylsilyl)phosphite in one step. Keywords: bisphosphonate; Fe2O3 nanoparticle; polyethylene glycol derivatives; surface ligand synthesis; Introduction Numerous researchers are interested in

Artificial Diels–Alderase based on the transmembrane protein FhuA

• Hassan Osseili,
• Daniel F. Sauer,
• Klaus Beckerle,
• Marcus Arlt,
• Tomoki Himiyama,
• Tino Polen,
• Akira Onoda,
• Ulrich Schwaneberg,
• Takashi Hayashi and
• Jun Okuda

Beilstein J. Org. Chem. 2016, 12, 1314–1321, doi:10.3762/bjoc.12.124

• ), NaPi (sodium phosphate buffer). CD spectra of refolded catalysts 17–19 (red: 17, black: 18, blue: 19). Temperature-dependent CD spectra of catalyst 17. MALDI–TOF mass spectra (black: 17, red: FhuAΔCVFtev). Syntheses to Cu(I) complex bearing a NHC ligand. Synthesis of Cu(II) terpyridyl complexes

A modular approach to neutral P,N-ligands: synthesis and coordination chemistry

• Vladislav Vasilenko,
• Torsten Roth,
• Clemens K. Blasius,
• Sebastian N. Intorp,
• Hubert Wadepohl and
• Lutz H. Gade

Beilstein J. Org. Chem. 2016, 12, 846–853, doi:10.3762/bjoc.12.83

• . In addition, the resulting ligand families should provide nitrogen and phosphorus donors with varying donor strength (amidine vs imine, phosphine vs heteroatom-bound phosphorus) and different bite angles (five- vs six-membered chelate rings). Results and Discussion Ligand synthesis We based the

An improved procedure for the preparation of Ru(bpz)₃(PF₆)₂ via a high-yielding synthesis of 2,2’-bipyrazine

• Danielle M. Schultz,
• James W. Sawicki and
• Tehshik P. Yoon

Beilstein J. Org. Chem. 2015, 11, 61–65, doi:10.3762/bjoc.11.9

• suited for oxidatively induced photoredox transformations. We present here a straightforward and high-yielding route to Ru(bpz)3(PF6)2 that features an improved Pd-catalyzed synthesis of the 2,2’-bipyrazine ligand that is amenable to gram-scale preparations. Keywords: heterocycles; ligand synthesis

Enantioselective synthesis of planar chiral ferrocenes via palladium-catalyzed annulation with diarylethynes

• Yan-Chao Shi,
• Rong-Fei Yang,
• De-Wei Gao and
• Shu-Li You

Beilstein J. Org. Chem. 2013, 9, 1891–1896, doi:10.3762/bjoc.9.222

• (ethyl acetate/petroleum ether 1:10, v/v, 3% Et3N) to afford the desired product 3. Design of the planar chiral P,N-ligand. Synthesis of planar chiral P,N-ligand (Sp)-L1. Pd-catalyzed asymmetric allylic alkylation and amination reactions with (Sp)-L1. Examination of ligands, temperature and additivesa

Synthesis of 5-(ethylsulfonyl)-2-methoxyaniline: An important pharmacological fragment of VEGFR2 and other inhibitors

• Miroslav Murár,
• Gabriela Addová and
• Andrej Boháč

Beilstein J. Org. Chem. 2013, 9, 173–179, doi:10.3762/bjoc.9.20

• -(ethylsulfonyl)-2-methoxy-1,3-dinitrobenzene (4a) have been precisely physicochemically characterised. Keywords: angiogenesis; pharmacophoric ligand; synthesis of 5-(ethylsulfonyl)-2-methoxyaniline; VEGFR2 tyrosine kinase inhibitors; Introduction 5-(Ethylsulfonyl)-2-methoxyaniline (5) is a starting material

New efficient ligand for sub-mol % copper-catalyzed C–N cross-coupling reactions running under air

• Per-Fredrik Larsson,
• Peter Astvik and
• Per-Ola Norrby

Beilstein J. Org. Chem. 2012, 8, 1909–1915, doi:10.3762/bjoc.8.221

• mono-methylating ethylene amines were ineffective for the ethylenediamine motif; hence, there is an opportunity for further ligand synthesis development. Experimental General: All the experiments were carried out under inert atmosphere (nitrogen). DMEDA, iodobenzene and dodecane were distilled over

Recent advances in the development of alkyne metathesis catalysts

• Xian Wu and
• Matthias Tamm

Beilstein J. Org. Chem. 2011, 7, 82–93, doi:10.3762/bjoc.7.12

• ]cycloaddition/cycloreversion mechanism (Scheme 1). Alkylidyne complexes 9 and 10. Alkyne metathesis based on the Katz mechanism. Reaction patterns of alkyne metathesis. Typical examples from traditional catalyst systems. Ligand synthesis and catalyst design. Catalysts synthesis using high- and low-oxidation

Bis(oxazolines) based on glycopyranosides – steric, configurational and conformational influences on stereoselectivity

• Tobias Minuth and
• Mike M. K. Boysen

Beilstein J. Org. Chem. 2010, 6, No. 23, doi:10.3762/bjoc.6.23

• yield. To prepare an allo-configured precursor for ligand synthesis, we decided first to use a previously described epimerisation sequence for 7 featuring Swern oxidation and subsequent reduction with sodium borohydride [25]. In our hands this method led to an inseparable product mixture in the second